Spinal Fusion: Lateral Lumbar Interbody Fusion (LLIF)Open pdf


Lateral interbody fusion is a minimally invasive surgery to treat disc problems in the low back. In spinal fusion, two or more bones of the spine are joined to stop painful motion, decompress pinched nerves, and correct scoliosis. Through a small incision at the side of the waist, the disc is removed and a bone graft is inserted to restore the height and relieve nerve pinching. During healing, the bones fuse into one solid piece.

Figure 1. (side view) A collapsed degenerative disc pinches the nerve between the bones, causing back pain and instability.

What is lateral spine fusion?

When back and leg pain result from injury or degenerative changes in the spine (Fig. 1), a lateral lumbar interbody fusion (LLIF) may be recommended. Fusion stabilizes the spine and prevents painful motion. The surgery is sometimes called DLIF, which stands for direct lateral interbody fusion, or XLIF, for extreme lateral interbody fusion. Both refer to the same technique.

During lateral fusion, an incision is made at the side of the waist. The damaged disc is removed and the space between the bony vertebrae is filled with a spacer bone graft. The spacer restores the height between the bones and relieves pinching of the spinal nerves. The graft becomes a bridge between the two bones to promote fusion. In some cases the graft is strengthened with a plate and screws on the side or with pedicle screws from the back.

As the body begins healing, new bone cells grow around the graft. After 3 to 6 months, the bone graft should fuse the two vertebrae, forming one solid piece of bone. Like reinforced concrete, instrumentation and fusion work together.

Depending on the symptoms, a one-level or multi-level fusion may be performed. A one-level fusion joins two bones while a two-level fusion joins three bones.

Figure 2
Figure 2. Through an incision made at the waist, lateral fusion (DLIF, XLIF) reaches the spine from the side. The disc is removed and replaced with a bone graft. Lateral fusion is an alternative to ALIF and TLIF surgeries.

Lateral spine fusion is a unique minimally invasive surgery for several reasons. First, the small incision is only 1 inch long near the waist. Second, its path to the spine is from the side (Fig. 2). The surgeon uses dilation tubes to create a tunnel between the patient's abdominal organs in front and the strong spine muscles in back. Third, a nerve-monitoring probe guides the path to safely enlarge the tubular instruments without injuring the spinal nerves. Lateral fusion can be performed in a hospital or as an outpatient same-day procedure.

Other types of spinal fusion surgery used to treat disc problems include ALIF, TLIF, PLIF, and AxiaLIF, each with its own advantages and disadvantages.

Who is a candidate?

You may be a candidate for LLIF if you have:

  • degenerative disc disease
  • low-grade spondylolisthesis
  • mild to moderate scoliosis
  • symptoms that have not improved with physical therapy or medication

You are not a candidate for LLIF if you have:

  • damaged disc at L5-S1, because the hip bone blocks access
  • severe spondylolisthesis or scoliosis
  • other problems that would prevent bone fusion
  • prior abdominal surgery near the kidneys

Fusion may be helpful in treating:

  • Degenerative disc: the drying and shrinkage of discs with age. As the disc thins or herniates, the vertebrae bones rub and pinch the nerves (Fig. 1).
  • Spondylolisthesis: a forward slip of a vertebra bone out of its normal position. It can kink and compress the nerves, causing pain.
  • Spinal stenosis: the narrowing of the spinal canal and nerve root canals. Enlarged facet joints and ligaments pinch the nerves causing pain and numbness in the legs.
  • Scoliosis: an abnormal curve of the spine caused by misalignment of the bones. In adults this occurs from aging discs, arthritis, or previous spine surgery.

The surgical decision

If you are a candidate for spinal fusion, the surgeon will explain your options. Consider all the risks and benefits as you make your decision. Fusion is performed only after other treatments have been explored. It will stop the motion in the painful area of your spine, allowing increased function and return to a more normal lifestyle—though one that may not be totally pain-free.

Your surgeon will also explain the various types of bone graft. These materials are placed within the remaining disc space and act as a kind of mortar between the bones as your body heals. Each type has advantages and disadvantages.

  • Autograft is your living bone. The marrow contains bone-growing proteins. It can be collected from drillings during the surgery or taken from the hip as an iliac crest bone graft. The harvested bone is about a half inch thick. The entire thickness of bone is not removed
  • BMA (bone marrow aspirate) is your living bone marrow, collected with a syringe from the hip (iliac bone) or vertebra. It is relatively painless compared to an iliac crest graft.
  • Allograft is bone from an organ donor, collected and stored by a bone bank. The donor graft has no bone-growing cells.
  • Cellular bone matrix is allograft from an organ donor that contains bone-growing stem cells. The putty is shaped and added to grafts.
  • BMP (bone morphogenetic protein) is sometimes added to bone-graft material to stimulate bone growth naturally in the body.

Who performs the procedure?

A neurosurgeon or orthopedic surgeon can perform spine surgery. Many spine surgeons have specialized training in minimally invasive surgery. Ask your surgeon about his or her training, especially if your case is complex or you have had previous spinal surgery.

What happens before surgery?

In the office, you will sign consent forms and provide your medical history (allergies, medicines/vitamins, bleeding history, anesthesia reactions, previous surgeries). Inform your healthcare provider about all the medications (over-the-counter, prescription, herbal supplements) that you are taking.Presurgical tests (e.g., blood test, electrocardiogram, chest X-ray) may need to be done several days before surgery. Consult your primary care physician about stopping certain medications and ensure you are cleared for surgery.

Continue taking the medications your surgeon recommends. Stop taking all non-steroidal anti-inflammatory medicines (ibuprofen, naproxen, etc.) and blood thinners (Coumadin, aspirin, Plavix, etc.) 7 days before surgery.

You may be asked to wash your skin with Hibiclens (CHG) or Dial soap before surgery. It kills bacteria and reduces surgical site infections. (Avoid getting CHG in eyes, ears, nose or genital areas.)

Stop smoking and drinking before surgery

The most important way to achieve a successful spine fusion is to eliminate tobacco use (cigarettes, vaping, cigars, pipes, chewing tobacco, and snuff / dip) before surgery.

Nicotine prevents bone growth and decreases successful fusion. Smoking risk is serious: fusion fails in 40% of smokers compared with 8% of non-smokers [1]. Smoking also decreases blood circulation, resulting in slower wound healing and increased risk of infection. Talk with your doctor about ways to help you quit smoking: nicotine replacements, medications (Chantix or Zyban), and tobacco counseling programs.

You should not drink alcohol 1 week before and 2 weeks after surgery to avoid bleeding problems.

Morning of surgery

  • Don’t eat or drink after midnight before surgery (unless the hospital tells you otherwise). You may take permitted medicines with a small sip of water.
  • Shower using antibacterial soap. Dress in freshly washed, loose-fitting clothing.
  • Wear flat-heeled shoes with closed backs.
  • Remove make-up, hairpins, contacts, body piercings, nail polish, etc.
  • Leave all valuables and jewelry at home.
  • Bring a list of medications with dosages and the times of day usually taken.
  • Bring a list of allergies to medication or foods.

Arrive at the hospital 2 hours before (outpatient surgery center 1 hour before) your scheduled operation to complete the necessary paperwork and pre-procedure work-ups. An anesthesiologist will talk with you and explain the effects of anesthesia and its risks.

What happens during surgery?

This surgery generally takes 1 to 2 hours, depending on how many spine levels are treated.

Step 1: prepare the patient

You will lie on the operative table and be given anesthesia. Once asleep, you will be positioned on your side; the waist area is cleansed and prepped.

Figure 3. (front view) A 1-inch skin incision is made at the waist, and a corridor (green area) is opened throught the psoas muscle to the disc.

Step 2: make the incision

A small 1- to 2-inch incision is made at the waist (Fig. 3). The surgeon gently makes a path between the abdominal cavity and the back muscles through the retroperitoneal space. This area contains fat as well as the kidney and colon, which are gently moved aside.

Figure 4. (cross section view) Using tubular dilators, the surgeon makes a corridor behind the abdominal wall through a fat-filled area called the retroperitoneal space. A monitoring probe detects the position of nerves along the side of the spine, and helps guide a safe path through the psoas muscle to the disc.

Step 3: locate the damaged disc

A monitoring probe is inserted to detect the nerves that form the sciatic nerve. Looking at the fluoroscope (a special x-ray), the surgeon carefully passes a long tube along the path through the psoas muscle to the disc (Fig. 4).

Figure 5. The disc is removed with tiny instruments through the tube retractor.

Step 4: remove the disc

Next, a series of dilator tubes are passed, one around the other, to separate the muscles and create a tunnel to the spine. Working through the tube, the surgeon removes the damaged disc (Fig. 5).

Step 5: prepare the disc space

The open disc space is measured and an appropriate sized spacer or bioplastic cage is selected. Progressively larger spacer trials are slid into the space to reopen the height and decompress the nerves. When height has been restored, the permanent spacer is prepared with bone graft.

Bone marrow is taken from the iliac crest with a syringe (or by incision) and then mixed with other graft material. The mortar-like paste contains bone-growing proteins that are packed into the spacer cage.

Figure 6. A spacer bone graft is inserted to restore the collapsed disc height, realign the bones, and relieve pinching of nerves.

Step 6. insert the bone graft

Guided by x-ray fluoroscopy, the spacer graft is inserted into the empty disc space, pushing the two bones apart to restore normal disc height (Fig. 6 and 7).

Figure 7. (front view) X-ray sequence shows opening of the disc space and increase in height as the bone graft is inserted.

Step 7. insert plate and screws (optional)

The spacer graft may be held in place with a metal plate screwed into the side of the vertebrae, or with screws and rods from the back. The hardware provides stability during fusion.

Step 8. close the incision

The tubes and instruments are removed. The skin incision is closed with Steri-Strips or biologic glue.

What happens after surgery?

You will awaken in the postoperative recovery area. Your blood pressure, heart rate, and respiration will be monitored. Any pain will be addressed. Once awake, you can begin gentle movement (sitting in a chair, walking). Most patients having a 1- or 2-level LLIF go home the same day. However, if any difficulty in breathing or unstable blood pressure occurs, the patient can stay overnight in the hospital.

Be sure to have someone at home to help you for the first 24 to 48 hours.

Follow the surgeon's home care instructions for 2 weeks after surgery or until your follow-up appointment. In general, you can expect:


  • Avoid bending or twisting your back.
  • Don't lift anything heavier than 5 pounds.
  • No strenuous activity, including yard work, housework, and sex.
  • DON'T SMOKE or use nicotine products: vape, dip, chew. It prevents new bone growth and may cause your fusion to fail.
  • Don't drive until after your follow-up visit.
  • Don't drink alcohol. It thins the blood and increases the risk of bleeding. Also, don't mix alcohol with pain medicines.

Incision Care

  • Wash your hands before and after cleaning your incision to prevent infection.
  • If Dermabond skin glue covers your incision, you may shower the day after surgery. Gently wash the area with soap and water every day. Don't rub or pick at the glue. Pat dry.
  • If you have staples, steri-strips, or stitches, you may shower 2 days after surgery. Gently wash the area with soap and water every day. Pat dry.
  • If there is drainage, cover the incision with a dry gauze dressing. If drainage soaks through two or more dressings in a day, call the office.
  • Don't soak the incision in a bath, pool or tub.
  • Don't apply lotion/ointment on the incision.
  • Dress in clean clothes after each shower. Sleep with clean bed linens. No pets in the bed until your incision heals.
  • Some clear, pinkish drainage from the incision is normal. Watch for spreading redness, colored drainage, and separation.
  • Staples, steri-strips, and stitches will be removed at your follow-up appointment.


  • Take pain medicines as directed by your surgeon. Reduce the amount and frequency as your pain subsides. If you don't need the pain medicine, don't take it.
  • Narcotics can also cause constipation. Drink lots of water and eat high-fiber foods. Laxatives and stool softeners such as Dulcolax, Senokot, Colace, and Milk of Magnesia are over-the-counter options.
  • If painful constipation does not get better, call the doctor to discuss other medicine.
  • Don't take anti-inflammatory pain relievers (Advil, Aleve) without your surgeon's approval. They prevent new bone growth and may cause your fusion to fail.
  • You may take acetaminophen (Tylenol).


  • Ice your incision 3-4 times per day for 15-20 minutes to reduce pain and swelling.
  • Don't sit or lie in one position longer than an hour unless you are sleeping. Stiffness leads to more pain.
  • Get up and walk 5-10 minutes every 3-4 hours. Gradually increase your walking time, as you are able.
  • If you were given a brace, wear it at all times except when sleeping, showering, or icing the incision.

When to Call Your Doctor

  • Fever over 101.5° (unrelieved by Tylenol).
  • Unrelieved nausea or vomiting.
  • Severe, unrelieved pain.
  • Unable to urinate 6-8 hours after surgery despite having a full bladder.
  • Signs of incision infection.
  • Rash or itching at the incision. It may be an allergy to Dermabond skin glue.
  • Swelling and tenderness in the calf of one leg (sign of a blood clot).
  • New onset of tingling, numbness, or weakness in the arms or legs.
  • Dizziness, confusion, nausea, or excessive sleepiness.

Recovery and prevention

Schedule a follow-up appointment with your surgeon for 2 weeks after surgery. Recovery time to daily activities is usually 6 to 12 weeks. X-rays may be taken after several weeks to verify that fusion is occurring. The surgeon will decide when to release you back to work at your follow-up visit.

Fusion takes time. Follow the "BLT" of spine surgery recovery by limiting your bending, lifting and twisting for 2 to 3 months. Work modifications may be necessary.

Recurrences of pain are common. The key to avoiding recurrence is prevention:

  • Proper lifting techniques
  • Good posture during sitting, standing, moving, and sleeping
  • Appropriate exercise program
  • An ergonomic work area
  • Healthy weight and lean body mass
  • A positive attitude and relaxation techniques (e.g., stress management)
  • Healthy diet of real foods
  • No smoking

What are the results?

As a minimally invasive procedure, lateral lumbar fusion uses a small incision, has short operating time, minimizes blood loss, and poses few serious complications. With its minimal trauma to the spine and nearby tissues, patients often return to daily activities within 6 weeks. Each patient's result and recovery differs based on his or her health and lifestyle. Keep a positive attitude and perform your physical therapy as instructed.

Figure 8. (side view) In this before and after x-ray of surgery, the bone graft restores the disc height. The LLIF relieves pinched nerves by enlarging the foramen where they exit the spine (green area). This is called indirect decompression. Screws may be inserted to keep the bones aligned during fusion.

The LLIF surgery commonly relieves painful pinched nerves by indirect decompression. By increasing the height of the disc space, more room is created for the nerves to move freely in the canals (Fig. 8). The surgeon does not see or touch the spinal nerves with instruments. By comparison, in a TLIF or PLIF surgery, the nerves are decompressed under direct vision.

Achieving a spinal fusion varies depending on the technique used, your general health, and whether you smoke.

What are the risks?

No surgery is without risks. General complications of any surgery include bleeding, infection, blood clots (deep vein thrombosis), and reactions to anesthesia.

Specific complications related to LLIF spinal fusion may include [1]:

Thigh weakness and/or pain. Because the surgical path crosses through the psoas muscle, you may have temporary thigh pain, groin numbness, and tingling that usually resolves in a couple of weeks. The thigh muscle may be weak and more difficult to flex at the hip. The weakness usually resolves in 3 to 6 months.

Injury to abdominal organs. Because the surgical path lies behind the abdominal cavity, there is a slight risk of injury to the bowel, kidney, ureter, and the major blood vessels lying on top of the spine.

Nerve injury. Muscle retraction can cause injury to the femoral or genitofemoral nerves in the psoas muscle.

Vertebrae fail to fuse. Common reasons why bones do not fuse include smoking and alcohol use, osteoporosis, obesity, and malnutrition. Nicotine is a toxin that inhibits bone-growing cells. If the fusion does not heal (pseudoarthrosis), another surgery may be needed for repair.

Hardware fracture. Metal screws that stabilize the spine may move or break before the bones are completely fused. Another surgery may be needed to fix or replace them.

Bone graft migration and settling. In rare cases, the bone graft moves from its correct position between the vertebrae soon after surgery. This more often occurs if hardware (plates and screws) is not used or if fusion was for several vertebral levels. Over time, the bone graft spacer may potentially sink into the bone (subsidence) and reduce the indirect decompression. If migration or subsidence occurs, another surgery may be needed to correct this.

Adjacent segment disease. Fusion causes extra stress and load transferred to the discs and bones above or below the fusion segment. The added wear and tear can eventually degenerate the adjacent level and cause pain.

Nerve damage or persistent pain. Any spine surgery comes with the risk of injury to the nerves or spinal cord. Damage can cause numbness or even paralysis. The most common cause of persistent pain is nerve damage from the disc herniation itself. If the damage was permanent, the nerve cannot respond to surgical decompression. Unlike memory foam, for example, the compressed nerve does not spring back. In such cases, spinal cord stimulation or other treatments may provide relief.

Sources & links

If you have more questions, please contact Mayfield Brain & Spine at 800-325-7787 or 513-221-1100.


1. Uribe JS, Deukmedjian AR. Visceral, vascular, and wound complications following over 13,000 lateral interbody fusions: a survey study and literature review. Eur Spine J 24 Suppl 3:420-6, 2015


Spine Universe
Know Your Back


allograft: a portion of living tissue taken from one person (the donor) and implanted in another (the recipient) to help fuse two tissues together.

autograft (autologous): a portion of living tissue taken from a part of one's own body and transferred to another part to fuse two tissues together.

bone graft: bone harvested from one's self (autograft) or from another (allograft) for the purpose of fusing or repairing a defect.

discectomy: a surgery to remove herniated disc material so that it no longer irritates and compresses the nerve root.

fusion: to join two separate bones into one to provide stability.

updated > 1.2021

reviewed by > Michael Kachmann, MD, William Tobler, MD, Mayfield Clinic, Cincinnati, Ohio

Mayfield Certified Health InfoMayfield Certified Health Info materials are written and developed by the Mayfield Clinic. We comply with the HONcode standard for trustworthy health information. This information is not intended to replace the medical advice of your health care provider.

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Patients who come to Mayfield with neck or back problems are given a rapid review of their medical condition within a few days, not weeks. It's a treatment process called Priority Consult.

Nearly 80 percent of our spine patients are able to recover with nonsurgical treatment. But when physical therapy, medications, and spinal injections fail to relieve pain, we help patients with surgery.

We perform more than 550 lumbar spinal fusion surgeries each year. Advances in technology and medical devices give our neurosurgeons the ability to operate on the spine with minimal disruption to the normal anatomy. Image-guided systems enable us to precisely insert pedicle screws, fusion devices, and other hardware. We are committed to using minimally invasive procedures whenever possible to speed your recovery.

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