Clinical Trials

Our Mission Includes Research

Mayfield has a long history of innovation and clinical research through the Mayfield Education and Research Foundation. Mayfield is a member of the the American Spine Registry that collect and share outcomes data to improve quality of care for all patients. We collaborate with industry to improve and test new surgical technologies and devices. We offer patients opportunity to participate in cutting-edge clinical trials. Learn more about current active trials for your diagnosis below:

Decreasing adjacent segment disease by strengthening the lumbar multifidus muscles
This study seeks to understand the role the multifidus muscle plays in recovery and prevention of adjacent level disease after lumbar fusion surgery. Using ultrasound, the multifidus muscles will be measured before and after a 1-2 level fusion between L3-S1 of the spine. All participants will follow a spinal stabilization and strengthening protocol. Five evaluations will be performed: baseline before surgery, 3-, 6-, 9-weeks after surgery, and 1 year follow-up interview.

Principal investigator: Robert Bohinski, MD, Megan Connett, DPT
Trial Sponsor: Mayfield Physical Therapy

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Brain Slice Explants to Predict Drug Response in Brain Tumors
This is a biospecimen collection study to evaluate the feasibility of engrafting and testing resected brain tumor tissue ex vivo to estimate drug response. CNS tumors display remarkable heterogeneity and unfortunately there are no reliable precision oncology platforms that can identify the most effective therapy for each patient.

Principal investigator: Yair Gozal, MD, PhD, Vince DiNapoli, MD, PhD
Trial Sponsor: UNC Lineberger Comprehensive Cancer Center

More info: ClinicalTrials.gov

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Complex Aneurysm Registry (CAR)

This is an observational registry study that will collect data on patients undergoing endovascular treatment for intracranial aneurysms with MicroVention devices. Patients will receive standard of care treatment as determined by their treating physician. Data will be collected from medical records and follow-up visits, including functional assessments, imaging, and safety information.

Principal investigator: Andrew Ringer, MD
Trial Sponsor: Microvention
More info: Clinicaltrials.gov

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CHESS: Chronic Subdural Hematoma Treatment with Embolization versus Surgery Study

The purpose of the CHESS trial is to evaluate the safety and efficacy of Middle Meningeal Artery Embolization (MMAE) against conventional surgery for patients with moderately symptomatic chronic subdural hematoma (cSDH).

Principal investigator: Andrew Ringer, MD
Trial Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

More info: ClinicalTrials.gov

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Chiari Surgical Success Scale trial
The Chiari Surgical Success Scale is a prospective multi-center patient registry that will combine patient data from all over the world to understand better how to treat and improve outcomes for patients suffering from Chiari type 1 malformation.

Principal investigator: Yair Gozal, MD, PhD
Trial Sponsor: Chiari Clinical Research Consortium

More info >

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CREST-2: Carotid Revascularization and Medical Management for Carotid Stenosis
The purpose of CREST-2 is to compare three different methods of stroke prevention to find the safest and most effective treatment. The stroke prevention methods include intensive medical management alone compared to intensive medical management in combination with a procedure to reopen the carotid artery in your neck (called revascularization) for treatment of plaque buildup. The two procedures available in this trial are carotid endarterectomy and carotid stenting. All study participants will receive intensive medical management to help control their risk factors for stroke.

Principal investigator: Andrew Ringer, MD
Trial Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
More info

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Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

The purpose of this observational registry study is to evaluate real-world clinical outcomes and patient-reported outcomes that measure the effectiveness and safety of STaRT. Patients (N=600) with surgically resected brain tumors of any pathology who have undergone STaRT are eligible. Data collected will include local control, overall survival, QOL, neurocognition, functional decline, and surgical and radiation-associated adverse events.

Principal investigator: Vince DiNapoli, MD, PhD
Trial Sponsor: GT Medical Technologies
More info

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Closed trials or in follow-up

Humanitarian Use Devices

Wingspan™ Stent for Blocked Brain Arteries
The purpose of this study is to monitor the effectiveness of the Wingspan Stent System to open arteries in the brain that have become blocked by a clot or narrowed by plaque.

Principal investigator: Andrew Ringer, MD

Neuroform™ Stent for Wide-neck Aneurysms
The purpose of this study is to monitor the effectiveness of the Neuroform Stent in treating wide-neck aneurysms in the brain.

Principal investigator: Andrew Ringer, MD

Onyx Liquid Embolic System HD-500
The purpose of this study is to monitor the effectiveness of the Onyx Liquid Embolic System in treating aneurysms in the brain.

Principal investigator: Andrew Ringer, MD

CORDIS ENTERPRISE™ Vascular Reconstruction Device & Delivery System
The purpose of this study is to monitor the effectiveness of the Cordis Enterprise Device in treating aneurysms in the brain.

Principal investigator: Andrew Ringer, MD

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