Essential tremorOpen pdf


Essential tremor (ET) is a disorder of the brain that causes a rhythmic trembling of the hands, arms, head, voice, legs, or trunk. It is different than a Parkinson's disease tremor. Treatments focus on reducing symptoms and maximizing quality of life. Treatments for this progressive disorder include medication, physical therapy, deep brain stimulation, and radiosurgery.

What is essential tremor?

Essential tremor is an uncontrollable shaking, which usually starts on one side of the body. Tremors occur during purposeful movement, such as when drinking, eating or writing. Many people find the shaking troublesome or embarrassing (Fig. 1). Also known as familial tremor, benign essential tremor, or hereditary tremor, this disorder affects some 10 million Americans. It is a progressive condition that gets worse over time. ET can be treated with medication or surgery, but not cured.

figure 1
Figure 1. In essential tremor, an area of the brain called the thalamus sends faulty electrical signals causing the hands, arms, head or voice to shake uncontrollably.

What are the symptoms?

Symptoms of essential tremor vary from person to person, as does the rate of progression.

  • Rhythmic tremors of the hands, legs, or trunk
  • Head nodding in a "no-no" or "yes-yes" motion
  • Voice quivering
  • Tremors that occur involuntarily and cannot be stopped.
  • Tremors that get worse during periods of stress and that lessen during rest.
  • In rare cases, mild gait disturbance.

Who is affected?

Essential tremor is more common after age 40 but can affect people of any age, including children. Essential tremor has a genetic component, a variant of the LINGO1 gene. The gene increases the risk of ET, but not everyone with the gene gets ET, and not everyone with ET has this particular genetic variant. Children of a parent with the essential tremor gene have a 50 percent chance of inheriting the gene.

What are the causes?

Scientists do not know the cause of essential tremor. The abnormal electrical brain activity is believed to occur between the thalamus and cerebellum connections. There is no way to prevent ET.

How is a diagnosis made?

There is no medical test that can confirm a diagnosis of ET. Your physician will review your medical history and family history, and will conduct a physical exam. He or she will explore whether another condition is causing your tremors by conducting a neurological exam and ordering laboratory tests. Your doctor also may give you a "performance test," in which you are asked to drink from a glass, hold your arms outstretched, write your name, or draw a spiral.

Essential tremor is sometimes misdiagnosed as Parkinson's disease. But whereas people with Parkinson's often have balance problems, slowness of movement, and freezing of gait, people with ET only rarely have problems in their legs.

What treatments are available?

Treatment depends on the symptoms and extent of disability caused by the tremor. If the tremor is mild, lifestyle adjustments may be all that are needed. As the condition progresses, medications or surgery can be used to relieve the symptoms.

Lifestyle changes

Caffeine and stress should be avoided, and good sleep is recommended. Your doctor may recommend physical therapy, which can improve your muscle strength. Adaptive devices, including wide-grip pens and eating utensils, may help you compensate for your tremor. Alcohol, used in moderation, can reduce tremor for short periods of time.


Your doctor may prescribe certain drugs or injections to help reduce the tremors. These include, but are not limited to:

  • Propranolol, a beta-blocker that is primarily used to treat high blood pressure
  • Anti-seizure medications, including primidone, gabapentin, and topiramate
  • Anti-anxiety medications, including clonazepam, diazepam, lorazepam, and alprazolam
  • Botulinum toxin injections for head and voice tremors

Surgical treatments

The goal of surgery is to reduce symptoms by modifying the abnormal signals that cause the tremor. This can be done with deep brain stimulation (DBS) or with radiosurgery.

DBS surgery involves implanting electrodes within the brain and connecting them to a stimulator device that resembles a pacemaker. The stimulator delivers electrical pulses to regulate brain activity. Radiosurgery creates a small, permanent lesion in the brain without a permanent implant.

Deep brain stimulation

In DBS surgery, an electrode is placed in a specific area of the brain (usually the thalamus). The electrode is placed on either the left or right side of the brain through a small hole made at the top of the skull. The electrode is connected by a long extension wire that is passed under the skin and down the neck to a battery-powered stimulator under the skin of the chest (Fig. 2). When turned on, the device sends electrical pulses to block the faulty nerve signals that cause tremors.

figure 2
Figure 2. In essential tremor, the thalamus is suspected of sending faulty messages, causing the shaking hands. A deep brain stimulator electrode can be placed inside the structure to regulate activity. The electrode is connected with a wire to a neurostimulator implanted under the skin of the chest. DBS is similar to a heart pacemaker.

DBS surgery is performed in two stages. Stage 1 is implantation of the electrodes in the brain. About one week later, Stage 2 is performed. This includes implantation of the stimulator device in the chest and tunneling of the wires to the neck.

You will use a handheld controller to turn the DBS system on and off. Your doctor will program the stimulator settings with a wireless device. The stimulation settings can be adjusted as your condition changes over time.

Most people don't feel the stimulation as it reduces their symptoms. However, some people may feel a brief tingling sensation when the stimulator is first turned on.

It's important to remember that essential tremor is progressive, and symptoms get worse over time. It is likely that you may need further programming in the future. See your neurologist or neurosurgeon when your condition changes.


Radiosurgery treatment of ET is an outpatient procedure in which highly focused radiation beams are used to destroy overactive cells that cause tremor. Radiation is delivered with pinpoint accuracy to the target, a small area in the thalamus called the ventral intermediate (VIM) nucleus (Fig. 3). The procedure is painless has few, if any, side effects.

figure 3
Figure 3. During radiosurgery, a high dose of radiation is delivered to a portion of the thalamus. Over time the radiation will damage the nerve cells and interrupt the signals causing tremor.

The two main technologies are the Leksell Gamma Knife and linear accelerator systems such as the BrainLab Novalis. A stereotactic head frame or facemask is attached to the patient's head to precisely localize the target area on an MRI scan and to hold the head perfectly still during treatment. Highly focused beams of radiation are delivered to the thalamus.

Radiation works by damaging DNA inside cells, making them unable to divide and grow. Patients typically experience a reduction in tremor a few months after treatment.

The surgical decision

Seek treatment at a center that offers significant experience, a team approach, and the full range of treatment options, including medication, surgery, and rehabilitation (physical, exercise, voice, balance).

Surgeries for essential tremor are performed by a neurosurgeon who has specialized training in functional neurosurgery.

The timing of when to consider surgery is different for each patient. If you have tremor despite optimal medications, then surgery should be considered. The type of surgery chosen will depend on your medical condition and personal needs. You and your physician can discuss which option is best for you.

Unlike other surgeries, such as pallidotomy, thalamotomy, or radiosurgery, DBS does not damage the brain tissue. Thus, if better treatments develop in the future, the DBS procedure can be reversed. (Three companies have FDA approval to manufacture DBS devices. Ask your physician about which one is best for you.)

Only the side that is most affected is treated first. Then it is up to the patient and physician to decide if the other side is to be operated on in the future.

What are the results?

Successful DBS is related to 1) appropriate patient selection, 2) appropriate selection of the brain area for stimulation, 3) precise positioning of the electrode during surgery, and 4) experienced programming and medication management. DBS for essential tremor may significantly reduce hand tremor in 60% to 90% of patients and may improve head and voice tremor.

Patients report other benefits of DBS. For example, better sleep, more involvement in physical activity, and improved quality of life.

Living with DBS

Once the DBS stimulator has been programmed, you are sent home with instructions for adjusting your own stimulation. The handheld controller allows you turn the stimulator on and off, select programs, and adjust the strength of the stimulation. Most patients keep their DBS system turned on 24 hours day and night. Some patients with essential tremor can use it during the day and turn off the system before bedtime. Your doctor may alter the settings on follow-up visits if necessary.

If your DBS has a rechargeable battery, you will need to use a charging unit. On average charging time is 1 to 2 hours per week. You will have a choice of either a primary cell battery or a rechargeable unit and you should discuss this with you surgeon prior to surgery.

Just like a cardiac pacemaker, other devices such as cellular phones, pagers, microwaves, security doors, and anti theft sensors will not affect your stimulator. Be sure to carry your Implanted Device Identification card when flying, since the device is detected at airport security gates.

Sources & links

If you have any questions, please call Mayfield Brain & Spine at 513-221-1100 or 800-325-7787.



basal ganglia: a mass of nerve cell bodies (gray matter) located deep within the white matter of the cerebrum. Has connections with areas that subconsciously control movement.

electrode: a conductor that carries electrical current.

pallidotomy: a surgical procedure that destroys the nerve cells in the globus pallidus of the brain. Used to treat the symptoms of rigidity and tremor.

stereotactic: use of three-dimensional coordinates to precisely locate deep brain structures.

thalamus: a relay station for all sensory messages that enter the brain; part of the basal ganglia.

thalamotomy: a surgical procedure that destroys the nerve cells in the thalamus of the brain. Used to treat the symptoms of tremor or pain.

updated > 1.2018
reviewed by > George Mandybur, MD, Mayfield Clinic, Cincinnati, Ohio

Mayfield Certified Health InfoMayfield Certified Health Info materials are written and developed by the Mayfield Clinic. We comply with the HONcode standard for trustworthy health information. This information is not intended to replace the medical advice of your health care provider.

Mayfield services

Mayfield Brain & Spine is a leader in the treatment of movement disorders, which include Parkinson's disease, essential tremor, and dystonia. In collaboration with premier hospitals in the Greater Cincinnati-Northern Kentucky region, we perform about 120 deep brain stimulation surgeries a year.

We encourage patients to seek treatment at a medical center that offers a team approach and the full range of treatment options, including medication, surgery, and rehabilitation.

To make an appointment call 513-221-1100.