Radiosurgery of the brain (stereotactic)Open print version

Overview

Radiosurgery uses high-energy rays to destroy tumors and other diseases. Beams of radiation are aimed at the brain by a machine outside your body. Radiosurgery uses very high dose beams meant to kill all the cells in the target area. The beams are tightly focused and accurate in order to avoid damaging healthy cells. It is often given in a one-time therapy in a single day, or it can be broken into 2 to 5 treatments given over a week. Radiosurgery may be used as an alternative to traditional open brain surgery, which requires an incision.

What is stereotactic radiosurgery?

Radiation damages the DNA inside cells, making them unable to divide and grow. The benefits of radiation are not immediate but occur with time. Aggressive tumors, whose cells divide rapidly, tend to respond quickly to radiation. Over time, the abnormal cells die and the tumor may shrink. Benign tumors, whose cells divide slowly, may take several months to a year to show an effect.

Figure 1. Radiosurgery shapes the radiation beams to match the exact outline of the tumor and minimize exposure of healthy brain. The beams come from numerous angles and intersect at the tumor to produce a high dose. The red ring shows the maximum dose and each outer ring represents lower and lower doses.

Pinpoint accuracy is critical so that the lethal dose is applied only to the target itself and not to surrounding healthy tissue or critical structures (Fig. 1). To achieve the razor-sharp precision, computer image-guided technology is used to plan and carry out the procedure. The method of targeting an object by taking all three dimensions into account is called stereotaxis.

Radiosurgery may be given as a one-day session or divided into 2 to 5 treatments given over a week (hypofractionation). Delivering a fraction of the total radiation dose allows normal cells time to repair themselves between treatments and may reduce side effects. Doctors may advise radiosurgery as a standalone treatment or in combination with surgery, chemotherapy or immunotherapy. Radiation may be given before surgery to shrink a tumor or AVM or after surgery to stop the growth of tumor cells that remain.

The two main radiosurgery technologies are the Leksell Gamma Knife and linear accelerator systems, such as the BrainLab Novalis. Each technology has unique characteristics, but all accomplish the same goals:

1. Precisely locate the target (tumor, lesion)
2. Hold the target still
3. Accurately aim the radiation beam
4. Shape the radiation beam to the target
5. Deliver a specific radiation dose

 

What’s the difference?

RadioSURGERY
1-5 fractions
Delivers radiation at very high doses, a few times, to a highly focused area. Benefit is its rapid fall-off giving a less dose to normal cells.
RadioTHERAPY
5-33 fractions
Delivers radiation at lower doses, over multiple days, and to larger areas. Treats a “margin” of tissue around tumors.

 

Linear accelerator
(LINAC)

A single beam rotates around the patient multiple times always focused on the tumor. The patient is held in position with either a head frame or facemask.

Gamma Knife

192 beams are precisely targeted on the tumor, with each beam originating from a slightly different point. The patient is held in position with a head frame.

 

Who is a candidate?

You may undergo radiosurgery if you have a:

  • Benign tumor: acoustic neuroma, meningioma, pituitary adenoma, craniopharyngioma, hemangioblastoma, glomus tumor
  • Metastatic tumor: lung, breast, melanoma or other cancer that has spread to the brain
  • Primary brain tumor, such as malignant glioma
  • Arteriovenous malformation (AVM)
  • Cavernoma
  • Trigeminal neuralgia

Who performs the procedure?

The radiosurgery team consists of a neurosurgeon, radiation oncologist, medical physicist, oncology nurse, and sometimes a dosimetrist and radiation therapist. The neurosurgeon and radiation oncologist are responsible for prescribing radiosurgery, for determining the correct target and radiation dose, and for approving the treatment plan. The medical physicist and the dosimetrist are involved in the treatment planning and set up the equipment. The radiation therapist positions the patient in the machine and monitors the treatment while under the supervision of the physicians and physicist. The nurse manages the medications and any side effects.

What happens before treatment?

Consultation
Your first appointment is a consultation with a neurosurgeon or radiation oncologist. Your doctor will perform a physical exam and reconfirm your diagnosis based on the imaging studies (CT, MRI) and pathology reports. Your doctor will discuss with you the best type of radiation treatment for your particular tumor or lesion, explain the treatment process, and discuss the potential benefits and possible side effects. Once you have decided to proceed with treatment, you will sign consent forms.

What happens next varies, depending on whether your treatment involves a facemask or a head frame. A facemask and imaging (Steps 1-3) are performed 1 to 2 weeks prior to radiosurgery. If a head frame is used, all steps occur in one day.

What happens during treatment?

On the day of treatment, arrive at the center and check in with the receptionist. You may bring a friend or a relative with you for company. Please arrange for a family member or friend to drive you home after the treatment.

Depending on the target’s size and location, either a facemask or head frame will be used to hold your head completely still during treatment.

Figure 2. A thermoplastic mask is custom-fit to the contours of your face. The front and back pieces of mesh are secured to a U-shaped appliance that attaches to the treatment table to hold the head still.

Step 1: facemask or frame attachment
A stereotactic facemask is custom-made to fit your face exactly. It will be used during imaging and treatment to hold your head perfectly still. You will lie with your head on a cradle of mesh stretched between a U-shaped appliance. Strips of stretchy plastic are then placed across your forehead, under your nose, and over your chin. You will be asked to bite a small piece of plastic with your front teeth. Next, thermoplastic mesh is dipped into a water bath, making the mesh very flexible. The mesh is placed over the face and allowed to conform (Fig. 2). You will be able to easily breathe. Cold mitts help the mesh cool and harden. Creation of the mask takes about 30 minutes.

It may be necessary to use a stereotactic frame attached to your head with small pins. If so, you will receive intravenous sedation to minimize discomfort. While you are seated, the frame is temporarily positioned on your head with Velcro straps. The four pin sites are cleaned and injected with local anesthesia. You may receive a light sedative to minimize discomfort. You may feel some pressure as the pins are tightened. Placement of the head frame takes about 30 minutes and is well tolerated.

Figure 3. Reflective balls are placed on the facemask prior to CT scanning. Markers are seen on the CT scan and help pinpoint the exact coordinates of the tumor or lesion.

Step 2: imaging
Next you will undergo imaging scans while wearing the facemask or head frame. Reflective balls are placed on the facemask and worn during the CT scan (Fig. 3). These markers appear on the scan and help pinpoint the exact three-dimensional coordinates of the target in the brain. It may be necessary to obtain a new MRI scan.

After the scan, you will be taken to a private room and given a light snack while the doctors plan the radiation prescription for later the same day. Your family and friends may keep you company. If you had a head frame attached, it will remain in place until treatment is completed.

Figure 4. The computer creates a 3D view of your anatomy. A treatment plan determines the number and angle of beams, the size and shape of the radiation beams, and the radiation dose.

Step 3: treatment planning
Information about the tumor's location, size, and closeness to critical structures is gathered by the CT or MRI scan. Advanced computer software uses the scans to create a 3D view of your anatomy and the tumor (Fig. 4). Using the software, the radiation oncologist, neurosurgeon, and physicist work as a team to determine the:

  • appropriate target(s)
  • radiation dose
  • number and angle of treatment beams
  • size and shape of the beams to exactly match the tumor or target

Each individual beam is too weak to damage the healthy brain as it passes through on its way to the target. But at the intersection of all the beams, the energy dose is strong enough to destroy the tumor.

Step 4: position the patient
Once the radiation machine is calibrated and prepared for your specific treatment plan, you will lie on the table. The mask is placed over your face and secured to the table. If you have a head frame, it is secured to the treatment table.

Alignment lasers and x-rays position you correctly. Stereoscopic x-rays are taken and compared to the treatment plan. Any misalignments are corrected before treatment.

Figure 5. The facemask is secured to the treatment table and holds the patient's head perfectly still and positioned in the treatment field. The machine rotates around the patient, aiming radiation beams at the tumor.

Step 5: deliver the radiation
The therapist leaves the room and operates the machine from the control room. The team watches you through video monitors and speaks to you over an intercom. The machine and treatment table move every so often to deliver radiation beams from one or more directions (Fig. 5).

The machine is large and makes a humming noise as it moves around your head. Its size and motion may be intimidating at first. It may pass close to your body, but it will not touch you. You do not have to hold your breath—just breathe normally. Treatment may take 30 minutes or longer, depending on the number and complexity of targets.

What happens after treatment?

After treatment the therapist releases the facemask or head frame and helps you off the treatment table. If multiple treatments are planned, the facemask is stored at the center for your next session. You will return each day at your scheduled time to repeat steps 4 and 5 until all fractions of the complete dose are delivered. You may be prescribed medication for a few days or weeks after treatment.

If you had a head frame, the pins and frame are removed. You may have oozing from the pin sites and a mild headache. You may then gather your belongings and go home. Follow these instructions for care of the pin sites:

  1. If you have discomfort or tenderness around the pin sites, Tylenol may he