Jed Hartings, PhD

May 19, 2011
FOR IMMEDIATE RELEASE

CONTACT: Tom Rosenberger, APR
Communications Department
513-569-5260

Cindy Starr, MSJ
Communications Department
513-569-5236

 press release

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UC Researchers connect electrical disturbances in the brain to worse outcomes following neurotrauma

Research includes surprise finding that spreading depolarizations can last up to 16 minutes

CINCINNATI - Electrical disturbances that spread through an injured brain like tsunamis have a direct link to poor recovery and can last far longer than previously realized, researchers at the Mayfield Clinic and University of Cincinnati Neuroscience Institute (UCNI) have found.

The disturbances, known as cortical spreading depolarizations, are short-circuits (electrical failures) that occur in a localized, or specific, area of injury and result in dampened brain waves. Because of their localization, the depolarizations are invisible in routine electroencephalography (EEG) exams. But they represent an extreme change in voltage – up to 10 times greater than any brain pattern that is normally present.

"Over the last several years we’ve learned how to measure and record spreading depolarization in the human brain, and we have known that these depolarizations occur in many patients who have suffered neurotrauma," says Jed Hartings, PhD, Director of Clinical Monitoring for the Mayfield Clinic and Research Assistant Professor in UC’s Department of Neurosurgery. "But we didn’t know what they meant or whether they were relevant. For the first time we now know that they relate to worse outcomes for patients who have suffered trauma to the brain."

That finding, Dr. Hartings adds, could eventually lead to new therapies. "If we can find a way to stabilize the brain's electrical activity and block spreading depolarizations, perhaps we can improve patients’ outcomes."

An Advance Access, online version of the research, published April 7 by the neurology journal Brain, http://brain.oxfordjournals.org/ will appear online it its complete, paginated form today.

The observational, multi-site study of 53 patients represents the initial phase of a four-year $1.96 million grant awarded by the Department of Defense (DOD). The topic of spreading depolarizations is of keen interest to the U.S. military because head injuries have emerged as the signature wounds of the wars in Iraq and Afghanistan.

Of the study’s 53 participants, 10 had experienced the most severe form of depolarizations. All died or had severe disabilities six months after their injury.

"Spreading depolarizations, which occur in up to 60 percent of patients who have experienced serious neurotrauma, are electrical failures of the brain’s local networks," explains Dr. Hartings, the study’s principal investigator. "When these networks fail, brain waves can no longer be generated, and they become dampened, or depressed, in amplitude."

Dr. Hartings likens each brain cell, or neuron, to a battery. When spreading depolarization occurs, the cell discharges its electricity completely. "The neuron, once alive with electrical activity, stops working and has to be resuscitated with glucose and oxygen," Dr. Hartings says. "You could also liken it to a battery in your car. If it drains, then the car doesn’t work."

Because networks of the brain’s cortex are connected in a continuum, a depolarization triggered by an injury will spread across the cortex like a tsunami on the ocean. The wave of short-circuiting cells travels almost imperceptibly, at a speed of 1 to 5 millimeters per minute.

Previous studies had suggested that depolarizations would last no longer than 2 or 3 minutes. But Dr. Hartings and his team have shown that, after trauma, they can be very long-lasting. "We found that 25 percent of the cortical spreading depolarizations lasted longer than 3 minutes, with durations that ranged up to 16 minutes," Dr. Hartings says. "These are the types of depolarizations that are typically observed with a developing brain infarction, or stroke. It was a surprise to see them in trauma."

To measure depolarizations, Dr. Hartings and fellow researchers placed a linear strip of electrodes on the surface of the brain, near the injured area, during neurosurgery at UC Health University Hospital. Only patients who required neurosurgery to treat their injuries were enrolled in the study. The electrode strip records computerized brainwaves similar to those of an EEG. But whereas EEG electrodes are placed on the scalp, spreading depolarization electrodes must be placed inside the skull, on the surface of the brain. The electrodes are removed three to seven days after implantation, without additional surgery.

New technology enabled the researchers not only to determine whether or not spreading depolarizations were occurring, but also – for the first time – to measure their duration. "A new signal-processing technique that we developed allowed us to measure exactly how long the cerebral cortex remains short-circuited, or depolarized," Dr. Hartings says. "This measurement – called the direct-current shift duration – is a direct index of how harmful the depolarization is, and of the brain’s degree of injury."

The signal-processing technique is a computer program that Dr. Hartings and his colleagues published in 2009 in the Journal of Neurophysiology.

The spreading depolarization grant is being issued through the DOD’s Psychological Health and Traumatic Brain Injury (PH/TBI) Research Program (formerly known as the Post Traumatic Stress Disorder/TBI Research Program). Dr. Hartings’s co-investigator at UC is Lori Shutter, MD, Director of the Neurocritical Care Program at UCNI and Associate Professor of Neurosurgery and Neurology at UC. Also participating are researchers at the University of Miami, University of Pittsburgh, Virginia Commonwealth University and King’s College Hospital in London.

UC began enrolling patients in early 2009. Patients in the study are not U.S. soldiers, but rather individuals who have suffered brain injury through falls, vehicular accidents, or other misfortunes.

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The Mayfield Clinic is recognized as one of the nation's leading physician organizations for clinical care, education, and research of the spine and brain. Supported by 20 neurosurgeons, five neurointensivists, an interventional radiologist, and a pain specialist, the Clinic treats 25,000 patients from 35 states and 13 countries in a typical year. Mayfield's physicians have pioneered surgical procedures and instrumentation that have revolutionized the medical art of neurosurgery for brain tumors and neurovascular diseases and disorders.
The UC Neuroscience Institute, a regional center of excellence, is dedicated to patient care, research, education, and the development of new treatments for stroke, brain and spinal tumors, epilepsy, traumatic brain and spinal injury, multiple sclerosis, neuromuscular disorders, Alzheimer’s disease and memory disorders, Parkinson’s disease, disorders of the senses (swallowing, voice, hearing, pain, taste and smell), and psychiatric conditions (bipolar disorder, schizophrenia and depression).